Health & Medicine

Epigenetics

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Study of DNA modifications that do not change its sequence

The study of heritable phenotype changes that do not involve alterations in the DNA sequence.

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Epigenetics-targeted drugs: current paradigms and future challenges

This review discusses the current landscape of epigenetic-targeted therapies, including ongoing clinical trials for drugs like PF-06821497. It highlights both the therapeutic potential in oncology and the challenges remaining for clinical implementation.

Signal Transduction and Targeted Therapy·2024-11-26

Johns Hopkins Researchers Develop Early Cancer Detection Method Based on Epigenetic Instability

Researchers at Johns Hopkins have developed a new method for early cancer detection that utilizes markers of epigenetic instability. This advancement represents a significant step forward in diagnostic technology for oncology.

GenomeWeb·2026-01-08

Epigenetic regulation of CD8+ T cell exhaustion: recent advances and update

This article explores how DNA methylation and histone modifications create stable chromatin landscapes that drive and maintain CD8+ T cell exhaustion. It highlights the critical role of epigenetic and transcriptional regulation in immune response modulation.

Frontiers in Immunology·2026-09-17

Towards a better understanding of epigenetics and dynamic gene silencing and reactivation

Researchers have identified a conserved family of proteins responsible for the dynamic activation and de-activation of genes. This discovery improves our understanding of how silenced genes can be reactivated through epigenetic mechanisms.

ScienceDaily·2026-09-14

Targeting fetal hemoglobin induction in sickle cell anemia: Epigenetic and gene‑modifying therapeutic strategies

This review examines current epigenetic and gene-modifying strategies aimed at inducing fetal hemoglobin as a therapeutic approach for sickle cell anemia. It discusses the potential for these methods to improve patient outcomes.

International Journal of Epigenetics·2025-11-11

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